Unlike mitragynine, only very small amounts of this alkaloid are needed to lessen even the worst pain. similar to mitragynine, 7- hydroxymitragynine effects much of the same same receptor sites, but is much more potent by weight than mitragynine, and also has little to no directly stimulating effects. this hypothesis is supported by a post- mortem toxicological report from a kratom- associated fatality, where mitragynine and 7- oh were quantified in the blood and urine of the decedent. 40 interestingly, the mitragynine/ 7- oh ratios found in blood and urine were ∼ 7: 1 and ∼ 1. 5: 1, respectively. plus cbd oil capsules thc. it is our opinion that such high relative. probably no more addictive than the oxycodone i am taking now for my chronic pain. this plant is very good at helping reduce my pain, it is just taking all those caps that is a discomfort.
i sampled a bit of my alcohol extract, but it wasn' t the same. i thought perhaps i had not extracted the 7- hydroxymitragynine. albeit that 7- oh is about 100 times more potent than mitragynine and 13 times more potent than morphine. as it is not available in sufficient enough concentration in the leaf to have any real effect. to extract it from the leaf is also extremely difficult as it would need to be specifically isolated and the amount is so small. general description along with mitragynine, 7- hydroxymitragynine is an active alkaloid found in the plant mitragynine speciosa, commonly known as kratom. the compound possesses opioid agonistic activity with a potentcy 30- and 17- fold higher than that of mitragynine and morphine, respectively. 7- hydroxy- mitragynine is a potent partial opioid agonist ( could be a full agonist but i believe i read something about it acting on the mu- opioid receptors specifically). though content by weight in kratom is quite low compared to other alkaloids, it is currently believed to be one of the most active.
in their report, the authors rationalized the importance of 7- hydroxymitragynine ( 7- oh) as an active metabolite of mitragynine and a key mediator of its analgesic activity, thus providing the essential in vivo link signifying the pharmacological relevance of 7- oh. in a previous report, both mitragynine and 7- oh were found to display g protein. one of the most exciting developments to appear in recent kratom research, the alkaloid 7- hydroxymitragynine may hold the key to some of the herbal remedy’ s most powerful effects. previously unknown before 1994, this naturally occurring compound may soon replace mitragynine as the star alkaloid of kratom. 7- hydroxymitragynine is a terpenoid indole alkaloid from the plant mitragyna speciosa, commonly known as kratom. in mice, it is orally active and has analgesic effects. 7- hydroxymitragynine is an agonist at the μ- opioid receptor with a potency, calculated using pd ( 2) values, that is 30- fold higher than that of mitragynine and 17- fold higher than that of morphine, respectively. we offer extracts in various strengths and purities and for manufacturers we can also tailor make an extract to any specific strength required. 10% mitragynine full spectrum kratom alkaloid extract 8 times more potent than good 7 oh mitragynine extract quality leaf powder. 45% mitragynine full spectrum kratom alkaloid extract 36 times more potent than good quality leaf.